If your system isn’t upgraded enough, some mods might not work properly. If you’re planning on installing any mods that require the Skyrim Script Extender (SKSE), be sure to copy its folder to your Skyrim directory. If your computer has Mod Manager set up incorrectly, or the game doesn’t have access to certain system files because they are not owner-restricted, then troubleshooting can be difficult.
If you’re having problems with Skyrim, make sure that SKSE is installed and working properly. If all else fails, you may want to reach out to our team and see if we can help troubleshoot the issue. You can try installing new graphics card drivers if this is still a problem for you, but if that doesn’t help then you may need to reinstall skse 64. If you’re experiencing problems with Skyrim, it might be due to your skse64 drivers not working or that the game isn’t recognizing them. If you are experiencing problems with Skse not working on your PC, please contact our customer service team. Finally, make sure you’re logged into Steam when prompted and click OK to finish installing Skyrim SKSE Does SKSE work with Skyrim Special Edition 2021? Make sure your graphics drivers are up-to-date and then install SKSE if necessary by running skse_installer. If you launch the game from a shortcut in the start menu, update that shortcut first. If you use a desktop shortcut to launch the game normally, just update the shortcut to point to skse_loader.exe instead of TESV.exe or SkyrimLauncher.exe and then exit the game. To start Skyrim SKSE, you’ll need to launch the skse_loader.exe file. Finally, select both folders and right click to “Add to archive.” How do I start Skyrim SKSE se? Next, copy the Scripts folder to SKSE’s main folder.
To install Skyrim SKSE from Steam, first download and install the Scripts folder.
Source: How do I install Skyrim SKSE from steam?
HOW TO INSTALL SKSE STEAM .EXE
exe files from the SKSE folder, which you can verify are copied correctly. If you want to use SKSE files with Skyrim, it’s important to copy the files from the SKSE folder to your Skyrim directory.